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pentobarbital will lessen the extent or effect of fludrocortisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will decrease the level or impact of norgestrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Moderate CYP3A4 inducers may minimize progestin